Resources

Practice Problems

To master retrosynthesis, you need a good approach and plenty of practice. Here you will find a range of retrosynthetic problems and guided solutions to help with disconnecting key functional groups.

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Problem 1

Disconnections include: alcohols, acylations, alkynes.

Problem 2

Disconnections include: alkenyl halides, aldehydes, pyridine-N-oxides.

Problem 3

Disconnections include: alcohols, alkynes, alkenes, acylations.

Problem 4

Disconnections include: amides, acids, nitriles.

Problem 5

Disconnections include: azides, alkynes.

Problem 6

Disconnections include: Diels-Alder, lactones.

Problem 7

Disconnections include: to be confirmed.